October 1, 2020 at 8:15 pm

Physics Colloquium | Novel Biomaterials for Bone Repair and Regeneration, Oct. 16

The Physics & Astronomy Colloquium Series presents Mei Wei of Ohio University on “Novel Biomaterials for Bone Repair and Regeneration,” on Friday, Oct. 16, at 4:10 p.m. at an Online Departmental Colloquium.

Abstract: More than 1.3 million bone-repair procedures are performed annually in the USA due to trauma, disease or aging, and a large proportion of them is for large bone defects. Unfortunately, reconstruction of large bone segments remains a challenge. The rapid growth in tissue engineering has offered tremendous promises for organ repair and regeneration. Among them, the development of skeletal tissues has become the fastest developing segment of tissue engineering due to the large demand in bone repair materials. Structurally, bone is a composite comprising fibrous collagen reinforced with nano-sized apatite ceramic particles.

In this talk, I will present a newly developed biomimetic apatite/fibrous collagen composite scaffold mimicking the arrangement of organic and inorganic components in natural bone. This scaffold not only demonstrates a biomimetic structure, but also exhibits superior mechanical properties and excellent in vivo performances for bone repair and regeneration. Besides the biomimetic scaffold, I will also briefly discuss a new approach for preparing a biomimetic apatite coating on metallic implants. The coating features a unique gradient porous structure for enhanced bone-implant integration. Finally, I will introduce a biomimetic, bioresorbable bone fixation composite material, which is the first of its kind that has sufficient strength, appropriate stiffness, and good toughness to support the mending bone. The new composite directly addresses long-standing problems associated with both existing bioresorbable and with commonly-used metallic bone fixtures, and thereby significantly improve the quality of the repaired bone.

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