March 1, 2020 at 4:30 pm

Virtual Quantitative Biology Seminar | Topological Data Analysis for Biological Ring Channels, March 31

Veronica Ciocanel, portrait

Dr. Veronica Ciocanel

The Quantitative Biology Seminar presents Dr. Veronica Ciocanel discussing “Topological Data Analysis for Biological Ring Channels” on March 31 from 4 to 5 p.m.

Ciocanelis a Presidential Postdoctoral Scholar at the Mathematical Bioscience Institute at Ohio State University.

Abstract: Contractile rings are cellular structures made of actin filaments that are important in development, wound healing, and cell division. In the reproductive system of the worm C. elegans, ring channels allow nutrient exchange between developing egg cells and the worm and are regulated by forces exerted by myosin motor proteins.

In this talk, I will present an agent-based modeling and data analysis framework for the interactions between actin filaments and myosin motor proteins inside cells. This approach may provide key insights for the mechanistic differences between two motors that are believed to maintain the rings at a constant diameter. In particular, we propose tools from topological data analysis to understand time-series data of filamentous network interactions. Our proposed methods clearly reveal the impact of certain parameters on significant topological circle formation, thus giving insight into ring channel formation and maintenance.


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