November 20, 2014 at 6:15 pm

CMSS Colloquium: ‘Super-Resolution Fluorescence Imaging: Seeing Single-Molecule Dynamics at Interfaces,’ Nov. 20

Jixin Chen

Jixin Chen

The Condensed Matter & Surface Sciences Colloquium Series presents Jixin Chen on “Super-Resolution Fluorescence Imaging: Seeing Single-Molecule Dynamics at Interfaces” on Thursday, Nov. 20, at 4:10 p.m. in Walter Lecture Hall 245.

Abstract: Super-resolution optical microscopy/nanoscopy has greatly extended our understanding of many systems, such as living cell structures and dynamics, and catalytically hot-spots on a nanoparticle. Super-resolution techniques allow the capture of images with a higher resolution than the diffraction limit, ~250 nm for a typical fluorescence image.

In this talk, Dr. Chen will first introduce the principles of super-resolution optical microscopies, especially the single-molecule localization method. Then he will share his experience in the application of a super-resolution imaging technique in the measurement of single protein-ligand interaction, which is motivated by the pharmaceutical industry for protein separation with ion-exchange chromatography. He will also share his plan to apply super-resolution microscopy in DNA imaging and sequencing.

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