The Physics & Astronomy Colloquium Series presents Peter A. Tass, of Stanford, on “Long-lasting Therapeutic Effects by Desynchronizing Neuromodulation” on Friday, Feb. 8, at 4:10 p.m. in Clippinger Labs 194.
Neurocircuit
Abstract: Several brain disorders are characterized by abnormal neuronal synchronization. A number of desynchronizing stimulation techniques have been computationally developed. Their initial goal was to disrupt synchrony in neural networks by delivering stimuli on demand. Taking into account plasticity of brain neuronal networks opened up the option to restore favorable neuronal coupling patterns and, hence, induce sustained, long-lasting desynchronizing effects which persist cessation of stimulation. In particular, coordinated reset (CR) stimulation disrupts abnormal neuronal synchrony and, mediated by synaptic plasticity, causes long-lasting desynchronization by reducing abnormal synaptic weights. CR stimulation can be realized with invasive and non-invasive stimuli and was validated in pre-clinical and clinical studies, e.g. with deep brain stimulation or vibrotactile CR stimulation for the treatment of Parkinson’s disease.
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