January 16, 2020 at 1:01 pm

Masson Co-Authors Paper in Top-Tier Chemistry Journal on Supramolecular Self-Sorting

Eric Masson studies pumpkin-shaped Cucurbituril molecules

Eric Masson studies pumpkin-shaped Cucurbituril molecules Photo: Rob Hardin

Dr. Eric Masson co-authored a paper on “Dual Layer” Self-Sorting with Cucurbiturils in the Journal of the American Chemical Society, a top-tier research journal with one of the highest impact factors in the chemical literature.

Masson is the Roenigk Chair and Associate Professor of Chemistry & Biochemistry at Ohio University. The other OHIO authors are post-doctoral researcher Héctor Barbero along with Nathan A. Thompson.

Masson and his coworkers are experts in supramolecular chemistry. This chemistry studies how different molecules interact with each other to form larger architectures. In this study, the authors show that combining three molecules (a pumpkin-shaped, hollow macrocycle called Cucurbit[8]uril, and two Platinum complexes) can yield, upon controlled scrambling, up to 10 different well-defined supramolecular assemblies.

This creation of diversity from just a few building blocks could be useful to quickly generate large numbers of bioactive agents to target proteins responsible for major diseases of our time.


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