Events

February 1, 2019 at 9:30 pm

Chemistry Colloguium | Integrating Mass Spectrometry-based Proteomics and Lipidomics Reveals Biomarkers and Altered Signaling Pathways, Feb. 11

Stephanie Cologna, portrait

Dr. Stephanie Cologna

Ohio University’s Chemistry and Biochemistry Colloquium Series presents Dr. Stephanie Cologna on “Integrating Mass Spectrometry-based Proteomics and Lipidomics Reveals Biomarkers and Altered Signaling Pathways During Progressive Neurodegeneration in Niemann-Pick Disease, type C1”, Monday, Feb. 11, at 4:10 p.m. in Clippinger 194.

Cologna is an Assistant Professor in the Department of Chemistry Laboratory for Integrated Neuroscience at the University of Illinois at Chicago.

The Host is Dr. Harrington.

Abstract: Advances in mass spectrometry technology have enabled large-scale differential analysis of proteins and lipids to investigate altered pathways in human disease. Our laboratory studies Niemann-Pick Disease, type C1 (NPC1) a lysosomal storage disorder with visceral involvement and progressive cerebellar neurodegeneration. Using a combination of differential proteomics, lipidomics and mass spectrometry imaging, we have identified new candidate biomarkers in a mouse model of NPC1. These alterations now provide a basis for evaluation in NPC1 patients and also can be used for therapeutic development. Several examples will be presented.

 

 

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