Chemistry Colloquium | Integrating Mass Spectrometry-based Proteomics and Lipidomics Reveals Biomarkers and Altered Signaling Pathways, Feb. 11

Dr. Stephanie Cologna

Ohio University’s Chemistry and Biochemistry Colloquium Series presents Dr. Stephanie Cologna on “Integrating Mass Spectrometry-based Proteomics and Lipidomics Reveals Biomarkers and Altered Signaling Pathways During Progressive Neurodegeneration in Niemann-Pick Disease, type C1”, Monday, Feb. 11, at 4:10 p.m. in Clippinger 194.

Cologna is an Assistant Professor in the Department of Chemistry Laboratory for Integrated Neuroscience at the University of Illinois at Chicago.

The Host is Dr. Harrington.

Abstract: Advances in mass spectrometry technology have enabled large-scale differential analysis of proteins and lipids to investigate altered pathways in human disease. Our laboratory studies Niemann-Pick Disease, type C1 (NPC1) a lysosomal storage disorder with visceral involvement and progressive cerebellar neurodegeneration. Using a combination of differential proteomics, lipidomics and mass spectrometry imaging, we have identified new candidate biomarkers in a mouse model of NPC1. These alterations now provide a basis for evaluation in NPC1 patients and also can be used for therapeutic development. Several examples will be presented.