January 1, 2019 at 6:45 pm

Quantitative Biology Seminar | Discovering Dynamic States of Neural Populations, Jan. 22

Tatiana Engel, portrait

Dr. Tatiana Engel

The Quantitative Biology Seminar series presents Dr. Tatiana Engel discussing “Discovering dynamic states of neural populations” on Jan. 22, at 4:10 p.m. in Morton 127.

The seminar is sponsored by the Quantitative Biology Institute.

Engel is Assistant Professor at Cold Spring Harbor Laboratory in New York.

Abstract: Neural responses and behavior are influenced by internal brain states, such as arousal or task context. Ongoing variations of these internal states affect global patterns of neural activity, giving rise to apparent variability of neural responses under the same experimental conditions. Uncovering dynamics of internal states from data proved difficult with traditional techniques based on trial-averaged responses of single neurons. In this talk, I will describe our recent work leveraging multi-electrode neural activity recordings and computational models to reveal internal-state dynamics of neural populations during perception and goal-directed behavior. I will show how endogenous fluctuations of ensemble neural activity in the primate visual cortex depend on the global arousal and selective attention. The spatiotemporal structure of these fluctuations accounts for correlated variability across cortical layers and columns. I will then present a broadly applicable, non-parametric framework for discovering neural population dynamics directly from the data, without a priori model assumptions, which can uncover dynamic computations from large-scale neural recordings with single-neuron, single-spike resolution.

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