Ohio University’s Chemistry and Biochemistry Colloquium Series presents Dr. Xiaodong (Mike) Shi on “1, 2, 3-Triazole: An Overlooked Ligand” on Monday, Feb. 1, at 4:30 p.m. in Clippinger Laboratories, Room 194.
Dr. Xiaodong (Mike) Shi
Shi is an Associate Professor of Chemistry at the University of South Florida.
Abstract: Some recent results on 1,2,3-triazole ligands promoted transition metal catalysis are described. With the significantly improved stability, the 1,2,3-triazole gold complexes successfully promoted the intramolecular hydroboration for the synthesis of cyclic aza-borane compounds, which provided new approaches in highly efficient azaborine synthesis under “open-flask” condition. In addition, through the mechanistic investigation, the triazole-dissociation was identified as rate-determination step, which led to the discovery of Lewis-acid assisted triazole-gold catalysis, achieving the sulfinic acid addition to Markovnikov addition to alkyne for the synthesis of vinyl sulfone. Meanwhile, the triazole was found as another effective directing group in Pd-catalyzed C-H activation, giving the oxidative olefination product using molecular oxygen in excellent yields.
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